1p9m: Difference between revisions
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[[Image:1p9m.gif|left|200px]] | [[Image:1p9m.gif|left|200px]] | ||
'''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex''' | {{Structure | ||
|PDB= 1p9m |SIZE=350|CAPTION= <scene name='initialview01'>1p9m</scene>, resolution 3.65Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= IL6ST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL6 OR IFNB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL6R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1P9M is a [ | 1P9M is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9M OCA]. | ||
==Reference== | ==Reference== | ||
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex., Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, Science. 2003 Jun 27;300(5628):2101-4. PMID:[http:// | Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex., Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, Science. 2003 Jun 27;300(5628):2101-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12829785 12829785] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: interleukin-6]] | [[Category: interleukin-6]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:42 2008'' | ||
Revision as of 11:21, 20 March 2008
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| 1p9m, resolution 3.65Å | |||||||||||||
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| Gene: | IL6ST (Homo sapiens), IL6 OR IFNB2 (Homo sapiens), IL6R (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Overview
Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3.65 angstrom-resolution structure of the extracellular signaling complex reveals a hexameric, interlocking assembly mediated by a total of 10 symmetry-related, thermodynamically coupled interfaces. Assembly of the hexameric complex occurs sequentially: IL-6 is first engaged by IL-6Ralpha and then presented to gp130in the proper geometry to facilitate a cooperative transition into the high-affinity, signaling-competent hexamer. The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint.
Disease
Known diseases associated with this structure: Kaposi sarcoma, susceptibility to OMIM:[147620], Osteopenia/osteoporosis OMIM:[147620]
About this Structure
1P9M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex., Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, Science. 2003 Jun 27;300(5628):2101-4. PMID:12829785
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