4fbn: Difference between revisions
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{{STRUCTURE_4fbn| PDB=4fbn | SCENE= }} | {{STRUCTURE_4fbn| PDB=4fbn | SCENE= }} | ||
===Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains=== | ===Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains=== | ||
{{ABSTRACT_PUBMED_23063561}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PLCG1_HUMAN PLCG1_HUMAN]] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.<ref>PMID:17229814</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4fbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBN OCA]. | [[4fbn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBN OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023063561</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphoinositide phospholipase C]] | [[Category: Phosphoinositide phospholipase C]] | ||
