1pgf: Difference between revisions

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[[Image:1pgf.gif|left|200px]]<br /><applet load="1pgf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1pgf.gif|left|200px]]
caption="1pgf, resolution 4.5&Aring;" />
 
'''PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL'''<br />
{{Structure
|PDB= 1pgf |SIZE=350|CAPTION= <scene name='initialview01'>1pgf</scene>, resolution 4.5&Aring;
|SITE= <scene name='pdbsite=COB:The+Cyclooxygenase+Active+Site+Is+Located+Within+A+Long+...'>COB</scene>, <scene name='pdbsite=COX:The+Cyclooxygenase+Active+Site+Is+Located+Within+A+Long+...'>COX</scene>, <scene name='pdbsite=PEB:The+Peroxidase+Active+Site+Is+At+The+Heme+(Hem+601)+Site+...'>PEB</scene> and <scene name='pdbsite=PER:The+Peroxidase+Active+Site+Is+At+The+Heme+(Hem+601)+Site+...'>PER</scene>
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=IMM:1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID'>IMM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1]
|GENE=
}}
 
'''PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1PGF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=IMM:'>IMM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] Known structural/functional Sites: <scene name='pdbsite=COB:The+Cyclooxygenase+Active+Site+Is+Located+Within+A+Long+...'>COB</scene>, <scene name='pdbsite=COX:The+Cyclooxygenase+Active+Site+Is+Located+Within+A+Long+...'>COX</scene>, <scene name='pdbsite=PEB:The+Peroxidase+Active+Site+Is+At+The+Heme+(Hem+601)+Site+...'>PEB</scene> and <scene name='pdbsite=PER:The+Peroxidase+Active+Site+Is+At+The+Heme+(Hem+601)+Site+...'>PER</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGF OCA].  
1PGF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGF OCA].  


==Reference==
==Reference==
Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site., Loll PJ, Picot D, Ekabo O, Garavito RM, Biochemistry. 1996 Jun 11;35(23):7330-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8652509 8652509]
Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site., Loll PJ, Picot D, Ekabo O, Garavito RM, Biochemistry. 1996 Jun 11;35(23):7330-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8652509 8652509]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Prostaglandin-endoperoxide synthase]]
[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: peroxidase]]
[[Category: peroxidase]]


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Retrieved from "https://proteopedia.org/1pgf"