1pj3: Difference between revisions

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[[Image:1pj3.gif|left|200px]]<br /><applet load="1pj3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1pj3.gif|left|200px]]
caption="1pj3, resolution 2.10&Aring;" />
 
'''Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate.'''<br />
{{Structure
|PDB= 1pj3 |SIZE=350|CAPTION= <scene name='initialview01'>1pj3</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=FUM:FUMARIC ACID'>FUM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Malate_dehydrogenase_(decarboxylating) Malate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.39 1.1.1.39]
|GENE= ME2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1PJ3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=PYR:'>PYR</scene>, <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=FUM:'>FUM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Malate_dehydrogenase_(decarboxylating) Malate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.39 1.1.1.39] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJ3 OCA].  
1PJ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJ3 OCA].  


==Reference==
==Reference==
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism., Tao X, Yang Z, Tong L, Structure. 2003 Sep;11(9):1141-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12962632 12962632]
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism., Tao X, Yang Z, Tong L, Structure. 2003 Sep;11(9):1141-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12962632 12962632]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Malate dehydrogenase (decarboxylating)]]
[[Category: Malate dehydrogenase (decarboxylating)]]
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[[Category: oxidative decarboxylase]]
[[Category: oxidative decarboxylase]]


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