1dz5: Difference between revisions
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{{STRUCTURE_1dz5| PDB=1dz5 | SCENE= }} | {{STRUCTURE_1dz5| PDB=1dz5 | SCENE= }} | ||
===The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein=== | |||
{{ABSTRACT_PUBMED_10742179}} | |||
== | ==Function== | ||
[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:010742179</ref><references group="xtra"/> | <ref group="xtra">PMID:010742179</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gunderson, S I.]] | [[Category: Gunderson, S I.]] | ||
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[[Category: Protein protein interaction]] | [[Category: Protein protein interaction]] | ||
[[Category: Ribonucleoprotein-rna complex]] | [[Category: Ribonucleoprotein-rna complex]] | ||
[[Category: Rna protein interaction]] | [[Category: Rna protein interaction]] | ||
