Sandbox Reserved 642: Difference between revisions
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'''Regulatory Domain''' | '''Regulatory Domain''' | ||
Housed in the N-terminus, the regulatory domain contains residues 19-142 and is more flexible than the other domains. The core of this domain contains an alpha beta sandwich and a beta alpha beta double motif. <ref> Bostjan Kobe, Ian G. Jennings, Colin M. House1, Belinda J. Michell, Kenneth E. Goodwill, Bernard D. Santarsiero, Raymond C. Stevens, Richard G. H. Cotton and Bruce E. Kemp. Nature Structural Biology 6, 442 - 448 (1999), Structural basis of autoregulation of phenylalanine hydroxylase, [http://http://www.nature.com/nsmb/journal/v6/n5/full/nsb0599_442.html]</ref> | Housed in the N-terminus, the regulatory domain contains residues 19-142 and is more flexible than the other domains. The core of this domain contains an alpha beta sandwich and a beta alpha beta double motif. <ref> Bostjan Kobe, Ian G. Jennings, Colin M. House1, Belinda J. Michell, Kenneth E. Goodwill, Bernard D. Santarsiero, Raymond C. Stevens, Richard G. H. Cotton and Bruce E. Kemp. Nature Structural Biology 6, 442 - 448 (1999), Structural basis of autoregulation of phenylalanine hydroxylase, [http://http://www.nature.com/nsmb/journal/v6/n5/full/nsb0599_442.html]</ref> | ||
The PheOH model protein was generated via x-ray crystallography.<ref> Erlandsen H., DirSci; Marianne G. Patch, PhD; Alejandra Gamez, PhD; Mary Straub; and Raymond C. Stevens, PhD. Structural Studies on Phenylalanine Hydroxylase and Implications Toward Understanding and Treating Phenylketonuria [http://www.pkuworld.org/home/docs/literature/erlandsen_2003_p.pdf]</ref> | The PheOH model protein was generated via x-ray crystallography.<ref> Erlandsen H., DirSci; Marianne G. Patch, PhD; Alejandra Gamez, PhD; Mary Straub; and Raymond C. Stevens, PhD. Structural Studies on Phenylalanine Hydroxylase and Implications Toward Understanding and Treating Phenylketonuria [http://www.pkuworld.org/home/docs/literature/erlandsen_2003_p.pdf]</ref> | ||
