Sandbox Reserved 641: Difference between revisions

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== '''Overview''' ==
== '''Overview''' ==
    Fuck this shit
 
== '''Structure''' ==
== '''Structure''' ==
Glutamate Dehydrogenase is a hexamer that is comprised of two trimer subunits.  These two subunits are stacked and composed of three domains.  The top of each domain contains a "NAD-binding domain" that has the conserved nucleotide-binding motif.  A larger helix-loop-helix structure rises above this and is referred to as an "antenna."  This antenna contains approximately 50 amino acids and plays a major role in regulation of the enzyme.  (1)
Glutamate Dehydrogenase is a hexamer that is comprised of two trimer subunits.  These two subunits are stacked and composed of three domains.  The top of each domain contains a "NAD-binding domain" that has the conserved nucleotide-binding motif.  A larger helix-loop-helix structure rises above this and is referred to as an "antenna."  This antenna contains approximately 50 amino acids and plays a major role in regulation of the enzyme.  (1)


== '''Mechanism''' ==
== '''Mechanism''' ==
L-Glutamate + NADP + H2O <--2-Oxoglutarate + NADPH + NH4+ + H+
[[Image:glutamatedehydrogenase.jpeg]]
 
Glutamate + NAD(P)+ + H2O <--> 2-Oxoglutarate + NH4 + + NAD(P)H.




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(1) http://www.sciencedirect.com.prox.lib.ncsu.edu/science/article/pii/S0968000408001898
(1) http://www.sciencedirect.com.prox.lib.ncsu.edu/science/article/pii/S0968000408001898
(2) http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1974.tb03565.x/pdf
(2) http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1974.tb03565.x/pdf
(3) http://onlinelibrary.wiley.com/doi/10.1002/prot.340120109/pdf
(4) http://www.sciencedirect.com/science/article/pii/S0969212699801014x/pdf
(3) http://onlinelibrary.wiley.com/doi/10.1002/prot.340120109/pdf
(3) http://onlinelibrary.wiley.com/doi/10.1002/prot.340120109/pdf
(4) http://www.sciencedirect.com/science/article/pii/S0969212699801014
(4) http://www.sciencedirect.com/science/article/pii/S0969212699801014
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