Sandbox Reserved 641: Difference between revisions
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<Structure load='1V9L' size='500' frame='true' align='right' caption='Glutamate Dehydrogenase' scene='Insert optional scene name here' /> | <Structure load='1V9L' size='500' frame='true' align='right' caption='Glutamate Dehydrogenase' scene='Insert optional scene name here' /> | ||
Glutamate Dehydrogenase (GDH)is an enzyme found in the mitochondria of most organisms. GDH is used to remove the ketone group and replace it with an α-amine group on the α-carbon, which forms glutmate. Glutamate is one of the 20 essential amino acids. This is done in reverse to supply α-ketoglutarate to the tricarboxylic acid (TCA) cycle. GDH is an oxidoreductase, which is an enzyme that transfers electrons from one molecule (reductant/electron donor) to another molecule (oxidant/electron acceptor). | Glutamate Dehydrogenase (GDH)is an enzyme found in the mitochondria of most organisms. GDH is used to remove the ketone group and replace it with an α-amine group on the α-carbon, which forms glutmate. Glutamate is one of the 20 essential amino acids. This is done in reverse to supply α-ketoglutarate to the tricarboxylic acid (TCA) cycle. GDH is an oxidoreductase, which is an enzyme that transfers electrons from one molecule (reductant/electron donor) to another molecule (oxidant/electron acceptor). | ||
Glutamate Dehydrogenase is a hexamer that contains two domains that have three subunits. GHD contains approximately 18 alpha helices and thirteen beta sheets. There is a large cleft that separates the two domains and allows for a substrate to enter and bind. The protein then closes around the substrate. For mammals only there is a structure that extends outward of the protein called the "antennae." | |||
== '''Structure''' == | == '''Structure''' == | ||
