Grb10 SH2 Domain: Difference between revisions
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==Introduction== | ==Introduction== | ||
Grb10 is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> | Grb10 (Growth factor Receptor-Binding protein) is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> | ||
==Dimerization of the Grb10 SH2 Domain== | ==Dimerization of the Grb10 SH2 Domain== | ||
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'''Why BPS-SH2?''' | '''Why BPS-SH2?''' | ||
In order for the full-length Grb10 protein to interact with Insulin Receptor Kinase (IRK), the SH2 and BPS domain must be present. <ref | In order for the full-length Grb10 protein to interact with Insulin Receptor Kinase (IRK), the SH2 and BPS domain must be present. <ref>PMID: 9506989</ref> | ||
</StructureSection> | </StructureSection> | ||
==Interaction Between Grb10 and E3 Ubiquitin Ligase NEDD4== | ==Interaction Between Grb10 and E3 Ubiquitin Ligase NEDD4== | ||
<Structure load='3M7F' size='350' frame='true' align='left' caption='Crystal structure of the Nedd4 C2/Grb10 SH2 complex PDB entry [[3M7F]])' scene='Insert optional scene name here' /> | <Structure load='3M7F' size='350' frame='true' align='left' caption='Crystal structure of the Nedd4 C2/Grb10 SH2 complex PDB entry [[3M7F]])' scene='Insert optional scene name here' /> | ||
There are 3 interfaces at chich Nedd4 C2 and Grb10 SH2 interact: | |||
<scene name='Grb10_SH2_Domain/Interface_i/1'>Interface I</scene> | |||
<scene name='Grb10_SH2_Domain/ | <scene name='Grb10_SH2_Domain/Interface_i/2'>hydrogen bonds between asn519 and leu177</scene> | ||
==Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling== | ==Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling== | ||
==References== | ==References== | ||
<references /> | |||
