Grb10 SH2 Domain: Difference between revisions

Revision as of 12:23, 8 November 2012 view source Jason Marks (talk \| contribs) 47 edits →There are 3 interfaces at which Nedd4 C2 and Grb10 SH2 interact: ← Older edit		Revision as of 12:24, 8 November 2012 view source Jason Marks (talk \| contribs) 47 edits →There are 3 interfaces at which Nedd4 C2 and Grb10 SH2 interact: Newer edit →
Line 44:		Line 44:


	<scene name='Grb10_SH2_Domain/Interface_iii/1'>Interface III</scene> is made of NEDD4 C2's proline rich C terminus which complexes with Grb10 H2 N-terminal residues 431-440 and C-terminal residues 532-535; among this interaction <scene name='Grb10_SH2_Domain/Interface_iii_hbond/1'>ARG533 (SH2) and PRO284 (C2)</scene> forms a hydrogen bond and <scene name='Grb10_SH2_Domain/Interface_iii_saltbridge/1'>ARG431 (SH2) and PRO287 (C2)</scene> forms a slat bridge		<scene name='Grb10_SH2_Domain/Interface_iii/1'>Interface III</scene> is made of NEDD4 C2's proline rich C terminus which complexes with Grb10 H2 N-terminal residues 431-440 and C-terminal residues 532-535; among this interaction <scene name='Grb10_SH2_Domain/Interface_iii_hbond/1'>ARG533 (SH2) and PRO284 (C2)</scene> forms a hydrogen bond and <scene name='Grb10_SH2_Domain/Interface_iii_saltbridge/1'>ARG431 (SH2) and PRO287 (C2)</scene> forms a slat bridge. <ref>PMID: 20980250</ref>

	==Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling==		==Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling==

Navigation menu