Grb10 SH2 Domain: Difference between revisions
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Grb10 (Growth factor Receptor-Binding protein) is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> | Grb10 (Growth factor Receptor-Binding protein) is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> | ||
[[Insulin-like growth factor 1 receptor]] | |||
growth suppressor | |||
==Dimerization of the Grb10 SH2 Domain== | ==Dimerization of the Grb10 SH2 Domain== | ||
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==Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling== | ==Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling== | ||
Many studies have shown that when mice are subjected to Grb10 gene disruption (chromosome 11) during prenatal life, they become approximately 30% larger in muscle mass, have improved glucose homeostasis, improved insulin sensitivity and reduced adiposity, i.e. fat storage, during their postnatal life <ref>PMID: 17562854</ref> <ref>PMID: 20980250</ref>. | |||
In humans, GRB10 has been mapped to chromosome 7p11.2–p12 (12). mUPD7 is observed in ≈10% of Silver–Russell syndrome (SRS) cases. This heterogeneous pediatric condition is characterized by severe growth retardation with relative sparing of the cranium (reviewed in ref. 13). While the imprinting status of human GRB10 seems complex and isoform-specific (14, 15), overexpression of GRB10 could result in the severe growth retardation seen in SRS.<ref>PMID: 17562854</ref> (WILL BE EDITED SHORTLY) | |||
==References== | ==References== | ||
<references /> | <references /> | ||
