1pxh: Difference between revisions

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[[Image:1pxh.jpg|left|200px]]<br /><applet load="1pxh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1pxh.jpg|left|200px]]
caption="1pxh, resolution 2.15&Aring;" />
 
'''Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2'''<br />
{{Structure
|PDB= 1pxh |SIZE=350|CAPTION= <scene name='initialview01'>1pxh</scene>, resolution 2.15&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SNA:N-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC+ACID'>SNA</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE= ptp1b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1PXH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SNA:'>SNA</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1N6W. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXH OCA].  
1PXH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1N6W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXH OCA].  


==Reference==
==Reference==
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor., Sun JP, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY, J Biol Chem. 2003 Apr 4;278(14):12406-14. Epub 2003 Jan 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12547827 12547827]
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor., Sun JP, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY, J Biol Chem. 2003 Apr 4;278(14):12406-14. Epub 2003 Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12547827 12547827]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: x-ray diffraction]]
[[Category: x-ray diffraction]]


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