1pzp: Difference between revisions

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[[Image:1pzp.gif|left|200px]]<br /><applet load="1pzp" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1pzp.gif|left|200px]]
caption="1pzp, resolution 1.45&Aring;" />
 
'''TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor'''<br />
{{Structure
|PDB= 1pzp |SIZE=350|CAPTION= <scene name='initialview01'>1pzp</scene>, resolution 1.45&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FTA:3-(4-PHENYLAMINO-PHENYLAMINO)-2-(1H-TETRAZOL-5-YL)-ACRYLONITRILE'>FTA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= bla ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1PZP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FTA:'>FTA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZP OCA].  
1PZP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZP OCA].  


==Reference==
==Reference==
Allosteric inhibition through core disruption., Horn JR, Shoichet BK, J Mol Biol. 2004 Mar 5;336(5):1283-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15037085 15037085]
Allosteric inhibition through core disruption., Horn JR, Shoichet BK, J Mol Biol. 2004 Mar 5;336(5):1283-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15037085 15037085]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: novel allosteric inhibitor]]
[[Category: novel allosteric inhibitor]]


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