Grb10 SH2 Domain: Difference between revisions

Revision as of 03:58, 13 November 2012 view source Jason Marks (talk \| contribs) 47 edits No edit summary ← Older edit		Revision as of 05:35, 13 November 2012 view source Jason Marks (talk \| contribs) 47 edits →Grb10 Gene Inhibition Affects Body Composition, and Insulin Signaling Newer edit →
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	[[Image:Tileshop-2.fcgi.png \| thumb \| alt=text \| Picture 2]]		[[Image:Tileshop-2.fcgi.png \| thumb \| alt=text \| Picture 2]]

			Picture 2 shows how inhibition of the Grb10 affects the overall growth of a mouse fetus. <ref>PMID: 166222</ref> In section a, it is shown that the wild-type and paternal Grb10 knockout mice have virtually the same weight, suggesting that it is not the paternal Grb10 allele that inhibits overally body mass. The middle bar represents the maternal knockout Grb10 mouse and shows an approximate 30% increase in overall weight when compare to wild-type. This data is visualized in section b, where the maternal Grb10 knockout mouse (left) sows a significant size difference when compared tot he wild-type mouse (right). Directly below section a, a bar graph representing the percent total body weight of specific vital organs. The liver shows an overall increase in percent body mass while the brain shows a slight decrease. More research must be done to determine why the brain and liver are specifically affected by Grb10 inhibition.

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