Grb10 SH2 Domain: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
No edit summary
Line 57: Line 57:
Picture 2 shows how inhibition of the Grb10 affects the overall growth of a mouse fetus. <ref>PMID: 166222</ref> In section a, it is shown that the wild-type and paternal Grb10 knockout mice have virtually the same weight, suggesting that it is not the paternal Grb10 allele that inhibits overally body mass.  The middle bar represents the maternal knockout Grb10 mouse and shows an approximate 30% increase in overall weight when compare to wild-type.  This data is visualized in section b, where the maternal Grb10 knockout mouse (left) sows a significant size difference when compared tot he wild-type mouse (right).  Directly below section a, a bar graph representing the percent total body weight of specific vital organs.  The liver shows an overall increase in percent body mass while the brain shows a slight decrease.  More research must be done to determine why the brain and liver are specifically affected by Grb10 inhibition.   
Picture 2 shows how inhibition of the Grb10 affects the overall growth of a mouse fetus. <ref>PMID: 166222</ref> In section a, it is shown that the wild-type and paternal Grb10 knockout mice have virtually the same weight, suggesting that it is not the paternal Grb10 allele that inhibits overally body mass.  The middle bar represents the maternal knockout Grb10 mouse and shows an approximate 30% increase in overall weight when compare to wild-type.  This data is visualized in section b, where the maternal Grb10 knockout mouse (left) sows a significant size difference when compared tot he wild-type mouse (right).  Directly below section a, a bar graph representing the percent total body weight of specific vital organs.  The liver shows an overall increase in percent body mass while the brain shows a slight decrease.  More research must be done to determine why the brain and liver are specifically affected by Grb10 inhibition.   


==Human Implications for Grb10 Inhibition==


In humans, GRB10 has been mapped to chromosome 7p11.2–p12 (12). mUPD7 is observed in ≈10% of Silver–Russell syndrome (SRS) cases. This heterogeneous pediatric condition is characterized by severe growth retardation with relative sparing of the cranium (reviewed in ref. 13). While the imprinting status of human GRB10 seems complex and isoform-specific (14, 15), overexpression of GRB10 could result in the severe growth retardation seen in SRS.<ref>PMID: 17562854</ref> (WILL BE EDITED SHORTLY)
The Grb10 gene is not only found in mice but also in humans on chromosome 7p11.2–p12. Approximately 10% of patients whom suffer Russell-Silver Syndrome, a disease associated with severe growth retardation, have a defect in chromosome 7, suggesting a linkage between Grb10 and poor growth in humans.<ref>PMID: 17562854</ref>


==References==
==References==
<references />
<references />
Retrieved from "https://proteopedia.org/Grb10_SH2_Domain"