1q0e: Difference between revisions
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'''Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase''' | {{Structure | ||
|PDB= 1q0e |SIZE=350|CAPTION= <scene name='initialview01'>1q0e</scene>, resolution 1.15Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] | |||
|GENE= | |||
}} | |||
'''Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1Q0E is a [ | 1Q0E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0E OCA]. | ||
==Reference== | ==Reference== | ||
Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 A., Hough MA, Hasnain SS, Structure. 2003 Aug;11(8):937-46. PMID:[http:// | Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 A., Hough MA, Hasnain SS, Structure. 2003 Aug;11(8):937-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12906825 12906825] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:31:25 2008'' | ||
Revision as of 11:31, 20 March 2008
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| 1q0e, resolution 1.15Å | |||||||||||||
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| Ligands: | CU, ZN and ACE | ||||||||||||
| Activity: | Superoxide dismutase, with EC number 1.15.1.1 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase
Overview
Copper zinc superoxide dismutase (CuZnSOD) forms a crucial component of the cellular response to oxidative stress by catalyzing the dismutation of the superoxide radical to hydrogen peroxide and water. Mutations in human CuZnSOD are associated with the development of familial amyotrophic lateral sclerosis (motor neuron disease). We have determined the structure of fully reduced bovine CuZnSOD to 1.15 A, the only atomic resolution structure for an intact CuZnSOD and one of only a small number for metalloproteins. For the first time, both subunits have been captured with the three coordinate Cu(I) ligation required by the generally accepted catalytic mechanism, where dismutation of the superoxide radical occurs via reduction of Cu. Furthermore, the improved resolution compared to previous studies (to 1.65 A) has allowed a more detailed examination of the metal center environment and its associated water network in the active site channel, facilitating the analysis of potential proton transfer routes.
About this Structure
1Q0E is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 A., Hough MA, Hasnain SS, Structure. 2003 Aug;11(8):937-46. PMID:12906825
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