Grb10 SH2 Domain: Difference between revisions
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The Grb10 gene is not only found in mice but also in humans on chromosome 7p11.2–p12. Approximately 10% of patients whom suffer from Russell-Silver Syndrome, a disease associated with severe growth retardation, have a defect in chromosome 7, suggesting a linkage between Grb10 and poor growth in humans.<ref>PMID: 17562854</ref> | The Grb10 gene is not only found in mice but also in humans on chromosome 7p11.2–p12. Approximately 10% of patients whom suffer from Russell-Silver Syndrome, a disease associated with severe growth retardation, have a defect in chromosome 7, suggesting a linkage between Grb10 and poor growth in humans.<ref>PMID: 17562854</ref> | ||
In recent news, Grb10 has been dubbed the "hulk protein" due to new findings of a new study from the Garvan Institute of Medical Research in Sydney, Australia. Researchers sought to find the skeletal muscle physiology of mice that had Grb10 deleted from their genome. They found that the enlargement of muscles was due to | In recent news, Grb10 has been dubbed the "hulk protein" due to new findings of a new study from the Garvan Institute of Medical Research in Sydney, Australia. Researchers sought to find the skeletal muscle physiology of mice that had Grb10 deleted from their genome. They found that the enlargement of muscles was due to the increase in numbers of myofibers in the muscle tissue, not myofiber size. <ref>PMID: 22623587</ref> The investigators also found that the Grb10-deficient mice muscles were metabolically no different then muscles found in wild-type mice. <ref>Name= Lowenna PMID: 22623587</ref> | ||
Once these findings were published, the media had a hay day writing about | Once these findings were published, the media had a hay day writing about the newly discovered "Hulk" Protein. Here are the titles of a few news articles found online regarding Grb10: | ||
[http://www.sci-news.com/medicine/article00560.html "Scientists Discover 'Hulk' Protein"] | [http://www.sci-news.com/medicine/article00560.html "Scientists Discover 'Hulk' Protein"] | ||
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[http://http://www.sciencedaily.com/releases/2012/08/120830130446.htm "Growing Strong Muscles Without Working Out? 'Hulk' Protein, Grb10, Controls Muscle Growth" ] | [http://http://www.sciencedaily.com/releases/2012/08/120830130446.htm "Growing Strong Muscles Without Working Out? 'Hulk' Protein, Grb10, Controls Muscle Growth" ] | ||
Dr. Lowenna J. Holt, Ph.D., the lead researcher was quoted saying, "By identifying a novel mechanism regulating muscle development, our work has revealed potential new strategies to increase muscle mass. Ultimately, this might improve treatment of muscle wasting conditions, as well as metabolic disorders such as Type 2 diabetes". Dr. Holt and colleagues did not set out to find a new way to increase the muscle mass for gym rats or competitive athletes but rather a new approach to treat patients that suffer from many different muscle wasting diseases. A lot more research must be done before it can be used on humans, but we may one day see the olympics testing for Grb10 inhibitors for they will most likely be abused as a new modern alternative to steroids. | |||
==References== | ==References== | ||
<references /> | <references /> | ||
