Fibrinogen binding protein: Difference between revisions
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C3B- opsonization- coats bug with IgG and allows phagocytosis<br> | C3B- opsonization- coats bug with IgG and allows phagocytosis<br> | ||
[http://en.wikipedia.org/wiki/Complement_system more about complement system]<br> | [http://en.wikipedia.org/wiki/Complement_system more about complement system]<br> | ||
[http:// | [http://www.bioscience.org/2009/v1s/af/11/fig1.jpg cascade process] | ||
'''Efb function''' is a protein that is secreted by Staphylococcous Aureus which mimics the natural proteins in the body that inhibit the complement system. These proteins are called regulator of complement activation(RCA). In general, RCA proteins suppress the activation of C3 and C4 by dissociating the subunits of C3 and/or C5 convertases or by acting as cofactors for factor I–dependent cleavage of C3b and/or C4b. <ref>PMID: 17351618</ref> Efb has been shown to bind to the C3d domain of C3 and C3B, inhibiting its function. | '''Efb function''' is a protein that is secreted by Staphylococcous Aureus which mimics the natural proteins in the body that inhibit the complement system. These proteins are called regulator of complement activation(RCA). In general, RCA proteins suppress the activation of C3 and C4 by dissociating the subunits of C3 and/or C5 convertases or by acting as cofactors for factor I–dependent cleavage of C3b and/or C4b. <ref>PMID: 17351618</ref> Efb has been shown to bind to the C3d domain of C3 and C3B, inhibiting its function. | ||
