HIV-1 Reverse Transcriptase in Complex with Nevirapine: Difference between revisions
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== Structure of RT domains == | == Structure of RT domains == | ||
[[image:RT Polymerase and RNase H domains.jpg|thumb|left|400px|'''RT Polymerase and RNase H domains. Reprinted from Esposito et al PMID:22778958''']] | [[image:RT Polymerase and RNase H domains.jpg|thumb|left|400px|'''RT Polymerase and RNase H domains. Reprinted from Esposito et al PMID:22778958''']] | ||
[[image:Subdomains of RT.jpg|thumb|right|400px|'''The subdomains of RT. Reprinted from Sluis-Cremer et al PMID:15544453''']] | |||
RT is an <scene name='HIV-1_Reverse_Transcriptase_in_Complex_with_Nevirapine/Nevirapine_ternary_complex/1'>asymmetric heterodimer</scene> composed of a 560 amino acid 66kDa subunit (p66) and a 440 amino acid 51kDa subunit (p51). The p66 and p55 domains are derived from cleavage of the same polyprotein precursor. The p51 is made from the C-terminal cleavage of the p66 subunit by HIV-1 protease. As a result, they share a common amino terminus, but the p51 subunit does not have an RNase H domain. | RT is an <scene name='HIV-1_Reverse_Transcriptase_in_Complex_with_Nevirapine/Nevirapine_ternary_complex/1'>asymmetric heterodimer</scene> composed of a 560 amino acid 66kDa subunit (p66) and a 440 amino acid 51kDa subunit (p51). The p66 and p55 domains are derived from cleavage of the same polyprotein precursor. The p51 is made from the C-terminal cleavage of the p66 subunit by HIV-1 protease. As a result, they share a common amino terminus, but the p51 subunit does not have an RNase H domain. | ||
