4bdt: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human acetylcholinesterase in complex with huprine W and fasciculin 2===

The ~~entry 4bdt is ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> [[http://www.uniprot.org/uniprot/TXFA2_DENAN TXFA2_DENAN]] This three-finger toxin selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish acetylcholinesterase (AChE) at picomolar concentrations. It is highly specific for the peripheral site on acetylcholinesterase. It has been called fasciculin since after injection into mice it cause severe, generalized and long-lasting (5-7 hours) fasciculations. The whole venom has anticoagulant activity, and the various components seem to act synergistically.

~~Authors~~: ~~Nachon, F~~.~~, Carletti, E~~.~~, Ronco, C~~.~~, Trovaslet, M~~.~~, Nicolet, Y~~.~~, Jean, L~~.~~, Renard, P~~.-Y.

==About this Structure==

[[4bdt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDT OCA].

~~Description~~: ~~Human acetylcholinesterase in~~ complex ~~with huprine W and fasciculin 2~~

==Reference==

[[Category: Acetylcholinesterase]]

[[Category: Dendroaspis angusticeps]]

[[Category: Homo sapiens]]

[[Category: Carletti, E.]]

[[Category: Jean, L.]]

[[Category: Nachon, F.]]

[[Category: Nicolet, Y.]]

[[Category: Renard, P Y.]]

[[Category: Ronco, C.]]

[[Category: Trovaslet, M.]]

[[Category: Alpha-beta hydrolase]]

[[Category: Butyrylcholinesterase]]

[[Category: Hydrolase-inhibitor complex]]

[[Category: Inhibition]]

[[Category: Nerve transmission]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bdt|  PDB=4bdt  |  SCENE=  }}
+===Human acetylcholinesterase in complex with huprine W and fasciculin 2===
+{{ABSTRACT_PUBMED_23679855}}
-The entry 4bdt is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>  [[http://www.uniprot.org/uniprot/TXFA2_DENAN TXFA2_DENAN]] This three-finger toxin selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish acetylcholinesterase (AChE) at picomolar concentrations. It is highly specific for the peripheral site on acetylcholinesterase. It has been called fasciculin since after injection into mice it cause severe, generalized and long-lasting (5-7 hours) fasciculations. The whole venom has anticoagulant activity, and the various components seem to act synergistically.
-Authors: Nachon, F., Carletti, E., Ronco, C., Trovaslet, M., Nicolet, Y., Jean, L., Renard, P.-Y.
+==About this Structure==
+[[4bdt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDT OCA].
-Description: Human acetylcholinesterase in complex with huprine W and fasciculin 2
+==Reference==
+<ref group="xtra">PMID:023679855</ref><references group="xtra"/><references/>
+[[Category: Acetylcholinesterase]]
+[[Category: Dendroaspis angusticeps]]
+[[Category: Homo sapiens]]
+[[Category: Carletti, E.]]
+[[Category: Jean, L.]]
+[[Category: Nachon, F.]]
+[[Category: Nicolet, Y.]]
+[[Category: Renard, P Y.]]
+[[Category: Ronco, C.]]
+[[Category: Trovaslet, M.]]
+[[Category: Alpha-beta hydrolase]]
+[[Category: Butyrylcholinesterase]]
+[[Category: Hydrolase-inhibitor complex]]
+[[Category: Inhibition]]
+[[Category: Nerve transmission]]