4g5y: Difference between revisions

Revision as of 14:15, 3 July 2013

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.^[1]

4g5y is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

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-'''Unreleased structure'''
+{{STRUCTURE_4g5y|  PDB=4g5y  |  SCENE=  }}
+===Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE===
-The entry 4g5y is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
-Authors: Ciulli, A., Silvestre, H.L., Blundell, T.L., Abell, C.
+==About this Structure==
+[[4g5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5Y OCA].
-Description: Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and fragment 11
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Pantoate--beta-alanine ligase]]
+[[Category: Abell, C.]]
+[[Category: Blundell, T L.]]
+[[Category: Ciulli, A.]]
+[[Category: Silvestre, H L.]]
+[[Category: Drug design]]
+[[Category: Fragment-based]]
+[[Category: Ligase]]
+[[Category: Ligase-ligase inhibitor complex]]
+[[Category: Pantothenate biosynthesis]]