4h6o: Difference between revisions
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{{STRUCTURE_4h6o| PDB=4h6o | SCENE= }} | |||
===Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole=== | |||
{{ABSTRACT_PUBMED_23448316}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref>[UniProtKB:P0A512] | |||
==About this Structure== | |||
[[4h6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6O OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Sterol 14-demethylase]] | |||
[[Category: Trypanosoma cruzi]] | |||
[[Category: Hargrove, T Y.]] | |||
[[Category: Lepesheva, G I.]] | |||
[[Category: Pollastri, M P.]] | |||
[[Category: Wawrzak, Z.]] | |||
[[Category: Cytochrome p450]] | |||
[[Category: Cytochrome p450 fold]] | |||
[[Category: Endoplasmic reticulum membrane]] | |||
[[Category: Eukaryotic membrane]] | |||
[[Category: Heme]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: Sterol biosynthesis]] | |||
Revision as of 07:42, 27 March 2013
Sterol 14-alpha demethylase (CYP51)from Trypanosoma cruzi in complex with the inhibitor NEU321 (1-(3-(4-chloro-3,5-dimethylphenoxy)benzyl)-1H-imidazole
Template:ABSTRACT PUBMED 23448316
Function
[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1][UniProtKB:P0A512]
About this Structure
4h6o is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
- ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200
