4ht2: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.===

~~The~~ entry ~~4ht2~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[http://omim.org/entry/143860 143860]]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref>

~~Authors~~: ~~Smirnov, A~~.~~, Manakova, E~~.~~, Grazulis, S~~.

==Function==

[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Reversible hydration of carbon dioxide.

~~Description~~: ~~Crystal structure of human carbonic~~ anhydrase ~~isozyme XII with the~~ inhibitor.

==About this Structure==

[[4ht2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HT2 OCA].

==Reference==

[[Category: Carbonate dehydratase]]

[[Category: Homo sapiens]]

[[Category: Grazulis, S.]]

[[Category: Manakova, E.]]

[[Category: Smirnov, A.]]

[[Category: Benzenesulfonamide]]

[[Category: Carbon-oxygen lyase activity]]

[[Category: Carbonate dehydratase activity]]

[[Category: Carbonic anhydrase]]

[[Category: Catalytic activity]]

[[Category: Drug design]]

[[Category: Lyase-lyase inhibitor complex]]

[[Category: Membrane]]

[[Category: Metal-binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ht2|  PDB=4ht2  |  SCENE=  }}
+===Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.===
+{{ABSTRACT_PUBMED_23394791}}
-The entry 4ht2 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[http://omim.org/entry/143860 143860]]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref>
-Authors: Smirnov, A., Manakova, E., Grazulis, S.
+==Function==
+[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Reversible hydration of carbon dioxide.
-Description: Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.
+==About this Structure==
+[[4ht2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HT2 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Carbonate dehydratase]]
+[[Category: Homo sapiens]]
+[[Category: Grazulis, S.]]
+[[Category: Manakova, E.]]
+[[Category: Smirnov, A.]]
+[[Category: Benzenesulfonamide]]
+[[Category: Carbon-oxygen lyase activity]]
+[[Category: Carbonate dehydratase activity]]
+[[Category: Carbonic anhydrase]]
+[[Category: Catalytic activity]]
+[[Category: Drug design]]
+[[Category: Lyase-lyase inhibitor complex]]
+[[Category: Membrane]]
+[[Category: Metal-binding]]