1q2p: Difference between revisions

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[[Image:1q2p.gif|left|200px]]<br /><applet load="1q2p" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1q2p.gif|left|200px]]
caption="1q2p, resolution 2.00&Aring;" />
 
'''SHV-1 class A beta-lactamase complexed with penem WAY185229'''<br />
{{Structure
|PDB= 1q2p |SIZE=350|CAPTION= <scene name='initialview01'>1q2p</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene> and <scene name='pdbligand=WY2:(6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID'>WY2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= BLA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])
}}
 
'''SHV-1 class A beta-lactamase complexed with penem WAY185229'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1Q2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae] with <scene name='pdbligand=MA4:'>MA4</scene> and <scene name='pdbligand=WY2:'>WY2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2P OCA].  
1Q2P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q2P OCA].  


==Reference==
==Reference==
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates., Venkatesan AM, Gu Y, Dos Santos O, Abe T, Agarwal A, Yang Y, Petersen PJ, Weiss WJ, Mansour TS, Nukaga M, Hujer AM, Bonomo RA, Knox JR, J Med Chem. 2004 Dec 16;47(26):6556-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15588091 15588091]
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates., Venkatesan AM, Gu Y, Dos Santos O, Abe T, Agarwal A, Yang Y, Petersen PJ, Weiss WJ, Mansour TS, Nukaga M, Hujer AM, Bonomo RA, Knox JR, J Med Chem. 2004 Dec 16;47(26):6556-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15588091 15588091]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: MA4]]
[[Category: MA4]]
[[Category: WY2]]
[[Category: WY2]]
[[Category: beta-lactam antibiotics]]
[[Category: beta-lactam antibiotic]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: hydrolase]]
[[Category: hydrolase]]
[[Category: inhibition]]
[[Category: inhibition]]


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Retrieved from "https://proteopedia.org/1q2p"