1q3i: Difference between revisions
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'''Crystal Structure of Na,K-ATPase N-domain''' | {{Structure | ||
|PDB= 1q3i |SIZE=350|CAPTION= <scene name='initialview01'>1q3i</scene>, resolution 2.6Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] | |||
|GENE= | |||
}} | |||
'''Crystal Structure of Na,K-ATPase N-domain''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1Q3I is a [ | 1Q3I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3I OCA]. | ||
==Reference== | ==Reference== | ||
The crystallographic structure of Na,K-ATPase N-domain at 2.6A resolution., Hakansson KO, J Mol Biol. 2003 Oct 3;332(5):1175-82. PMID:[http:// | The crystallographic structure of Na,K-ATPase N-domain at 2.6A resolution., Hakansson KO, J Mol Biol. 2003 Oct 3;332(5):1175-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14499619 14499619] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Sodium/potassium-exchanging ATPase]] | [[Category: Sodium/potassium-exchanging ATPase]] | ||
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[[Category: anti-parallel beta sheet]] | [[Category: anti-parallel beta sheet]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:32:31 2008'' | ||
Revision as of 11:32, 20 March 2008
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| 1q3i, resolution 2.6Å | |||||||||||||
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| Ligands: | NI | ||||||||||||
| Activity: | Sodium/potassium-exchanging ATPase, with EC number 3.6.3.9 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of Na,K-ATPase N-domain
Overview
The structure of the N-domain of porcine alpha(2) Na,K-ATPase was determined crystallographically to 3.2A resolution by isomorphous heavy-atom replacement using a single mercury derivative. The structure was finally refined against 2.6A resolution synchrotron data. The domain forms a seven-stranded antiparallel beta-sheet with two additional beta-strands forming a hairpin and five alpha-helices. Approximately 75% of the residues were superimposable with residues from the structure of Ca-ATPase N-domain, and a structure-based sequence alignment is presented. The positions of key residues are discussed in relation to the pattern of hydrophobicity, charge and sequence conservation of the molecular surface. The structure of a hexahistidine tag binding to nickel ions is presented.
About this Structure
1Q3I is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.
Reference
The crystallographic structure of Na,K-ATPase N-domain at 2.6A resolution., Hakansson KO, J Mol Biol. 2003 Oct 3;332(5):1175-82. PMID:14499619
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