2lpx: Difference between revisions

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[[~~Image~~:2lpx.~~png|left|200px~~]]

==Solution Structure of Strawberry Allergen Fra a 1e==

== Structural highlights ==

<table><tr><td colspan='2'>[[2lpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fragaria_x_ananassa Fragaria x ananassa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LPX FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FRAA1E.2, FRAA1E.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3747 Fragaria x ananassa])</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpx RCSB], [http://www.ebi.ac.uk/pdbsum/2lpx PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The PR10 family protein Fra a 1E from strawberry (Fragaria x ananassa) is down-regulated in white strawberry mutants, and transient RNAi (RNA interference)-mediated silencing experiments confirmed that Fra a 1 is involved in fruit pigment synthesis. In the present study, we determined the solution structure of Fra a 1E. The protein fold is identical with that of other members of the PR10 protein family and consists of a seven-stranded antiparallel beta-sheet, two short V-shaped alpha-helices and a long C-terminal alpha-helix that encompass a hydrophobic pocket. Whereas Fra a 1E contains the glycine-rich loop that is highly conserved throughout the protein family, the volume of the hydrophobic pocket and the size of its entrance are much larger than expected. The three-dimensional structure may shed some light on its physiological function and may help to further understand the role of PR10 proteins in plants.

~~{{STRUCTURE_2lpx| PDB=2lpx | SCENE= }}~~

Solution structure of the strawberry allergen Fra a 1.,Seutter von Loetzen C, Schweimer K, Schwab W, Rosch P, Hartl-Spiegelhauer O Biosci Rep. 2012 Dec 1;32(6):567-75. doi: 10.1042/BSR20120058. PMID:22913709<ref>PMID:22913709</ref>

~~===Solution Structure~~ of ~~Strawberry Allergen Fra a 1e===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

==~~About this Structure~~==

~~[[2lpx]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Fragaria_x_ananassa Fragaria x ananassa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPX OCA].~~

__TOC__

</StructureSection>

[[Category: Fragaria x ananassa]]

[[Category: Hartl-Spiegelhauer, O.]]

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-[[Image:2lpx.png|left|200px]]
+==Solution Structure of Strawberry Allergen Fra a 1e==
+<StructureSection load='2lpx' size='340' side='right' caption='[[2lpx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2lpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fragaria_x_ananassa Fragaria x ananassa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LPX FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FRAA1E.2, FRAA1E.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3747 Fragaria x ananassa])</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpx RCSB], [http://www.ebi.ac.uk/pdbsum/2lpx PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The PR10 family protein Fra a 1E from strawberry (Fragaria x ananassa) is down-regulated in white strawberry mutants, and transient RNAi (RNA interference)-mediated silencing experiments confirmed that Fra a 1 is involved in fruit pigment synthesis. In the present study, we determined the solution structure of Fra a 1E. The protein fold is identical with that of other members of the PR10 protein family and consists of a seven-stranded antiparallel beta-sheet, two short V-shaped alpha-helices and a long C-terminal alpha-helix that encompass a hydrophobic pocket. Whereas Fra a 1E contains the glycine-rich loop that is highly conserved throughout the protein family, the volume of the hydrophobic pocket and the size of its entrance are much larger than expected. The three-dimensional structure may shed some light on its physiological function and may help to further understand the role of PR10 proteins in plants.
-{{STRUCTURE_2lpx|  PDB=2lpx  |  SCENE=  }}
+Solution structure of the strawberry allergen Fra a 1.,Seutter von Loetzen C, Schweimer K, Schwab W, Rosch P, Hartl-Spiegelhauer O Biosci Rep. 2012 Dec 1;32(6):567-75. doi: 10.1042/BSR20120058. PMID:22913709<ref>PMID:22913709</ref>
-===Solution Structure of Strawberry Allergen Fra a 1e===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-==About this Structure==
+<references/>
-[[2lpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fragaria_x_ananassa Fragaria x ananassa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPX OCA].
+__TOC__
+</StructureSection>
 [[Category: Fragaria x ananassa]]
 [[Category: Hartl-Spiegelhauer, O.]]