1q68: Difference between revisions

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[[Image:1q68.gif|left|200px]]<br /><~~applet load~~=~~"1q68" size~~=~~"350" color~~=~~"white" frame~~=~~"true" align~~=~~"right" spinBox~~=~~"true"~~

[[Image:1q68.gif|left|200px]]

~~caption~~=~~"1q68"~~ />

'''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments'''~~<br />~~

{{Structure

|PDB= 1q68 |SIZE=350|CAPTION= <scene name='initialview01'>1q68</scene>

|SITE=

|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>

|ACTIVITY=

|GENE= CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments'''

==Overview==

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==Disease==

Known ~~diseases~~ associated with this structure: CD4 lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]

==About this Structure==

1Q68 is a [~~http://en.wikipedia.org/wiki/Protein_complex~~ Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].

1Q68 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].

==Reference==

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~14500983 14500983]

A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14500983 14500983]

[[Category: Homo sapiens]]

[[Category: Protein complex]]

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[[Category: zinc coordination]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 14~~:36:17 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:30 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1q68.gif|left|200px]]<br /><applet load="1q68" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1q68.gif|left|200px]]
-caption="1q68" />
-'''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments'''<br />
+ {{Structure
+|PDB= 1q68 |SIZE=350|CAPTION= <scene name='initialview01'>1q68</scene>
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
+|ACTIVITY=
+|GENE= CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), LCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==Disease==
-Known diseases associated with this structure: CD4  lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
+Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
 ==About this Structure==
-Q68 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].
+Q68 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q68 OCA].
 ==Reference==
-A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14500983 14500983]
+A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8., Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ, Science. 2003 Sep 19;301(5640):1725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14500983 14500983]
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
@@ Line 27: / Line 36: @@
 [[Category: zinc coordination]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:36:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:33:30 2008''