1bsx: Difference between revisions
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==Overview== | ==Overview== | ||
Combinatorial regulation of transcription implies flexible yet precise, assembly of multiprotein regulatory complexes in response to signals., Biochemical and crystallographic analyses revealed that hormone binding, leads to the formation of a hydrophobic groove within the ligand binding, domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL, motif-containing alpha-helix from GRIP1, a coactivator. Residues, immediately adjacent to the motif modulate the affinity of the, interaction; the motif and the adjacent sequences are employed to, different extents in binding to different receptors. Such interactions of, amphipathic alpha-helices with hydrophobic grooves define protein, interfaces in other regulatory complexes as well. We suggest that these, common structural . | Combinatorial regulation of transcription implies flexible yet precise, assembly of multiprotein regulatory complexes in response to signals., Biochemical and crystallographic analyses revealed that hormone binding, leads to the formation of a hydrophobic groove within the ligand binding, domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL, motif-containing alpha-helix from GRIP1, a coactivator. Residues, immediately adjacent to the motif modulate the affinity of the, interaction; the motif and the adjacent sequences are employed to, different extents in binding to different receptors. Such interactions of, amphipathic alpha-helices with hydrophobic grooves define protein, interfaces in other regulatory complexes as well. We suggest that these, common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity. | ||
==About this Structure== | ==About this Structure== | ||
1BSX is a | 1BSX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with T3 as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Sites: A and B. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BSX OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: specificity interaction site]] | [[Category: specificity interaction site]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:09:02 2007'' | ||
