1q7o: Difference between revisions
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'''Determination of f-MLF-OH Peptide Structure with solid-state magic-angle spinning NMR Spectroscopy''' | {{Structure | ||
|PDB= 1q7o |SIZE=350|CAPTION= <scene name='initialview01'>1q7o</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
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'''Determination of f-MLF-OH Peptide Structure with solid-state magic-angle spinning NMR Spectroscopy''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1Q7O is a [ | 1Q7O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7O OCA]. | ||
==Reference== | ==Reference== | ||
De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy., Rienstra CM, Tucker-Kellogg L, Jaroniec CP, Hohwy M, Reif B, McMahon MT, Tidor B, Lozano-Perez T, Griffin RG, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10260-5. Epub 2002 Jul 29. PMID:[http:// | De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy., Rienstra CM, Tucker-Kellogg L, Jaroniec CP, Hohwy M, Reif B, McMahon MT, Tidor B, Lozano-Perez T, Griffin RG, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10260-5. Epub 2002 Jul 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12149447 12149447] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Griffin, R G.]] | [[Category: Griffin, R G.]] | ||
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[[Category: mlf]] | [[Category: mlf]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:34:03 2008'' | ||
Revision as of 11:34, 20 March 2008
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Determination of f-MLF-OH Peptide Structure with solid-state magic-angle spinning NMR Spectroscopy
Overview
The three-dimensional structure of the chemotactic peptide N-formyl-l-Met-l-Leu-l-Phe-OH was determined by using solid-state NMR (SSNMR). The set of SSNMR data consisted of 16 (13)C-(15)N distances and 18 torsion angle constraints (on 10 angles), recorded from uniformly (13)C,(15)N- and (15)N-labeled samples. The peptide's structure was calculated by means of simulated annealing and a newly developed protocol that ensures that all of conformational space, consistent with the structural constraints, is searched completely. The result is a high-quality structure of a molecule that has thus far not been amenable to single-crystal diffraction studies. The extensions of the SSNMR techniques and computational methods to larger systems appear promising.
About this Structure
1Q7O is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy., Rienstra CM, Tucker-Kellogg L, Jaroniec CP, Hohwy M, Reif B, McMahon MT, Tidor B, Lozano-Perez T, Griffin RG, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10260-5. Epub 2002 Jul 29. PMID:12149447
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