1bt7: Difference between revisions
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==Overview== | ==Overview== | ||
The solution structure of the hepatitis C virus (BK strain) NS3 protein, N-terminal domain (186 residues) has been solved by NMR spectroscopy. The, protein is a serine protease with a chymotrypsin-type fold, and is, involved in the maturation of the viral polyprotein. Despite the knowledge, that its activity is enhanced by the action of a viral protein cofactor, NS4A, the mechanism of activation is not yet clear. The analysis of the, folding in solution and the differences from the crystallographic, structures allow the formulation of a model in which, in addition to the, NS4A cofactor, the substrate plays an important role in the activation of, the catalytic mechanism. A unique structural feature is the presence of a, zinc-binding site exposed on the surface, subject to a slow . | The solution structure of the hepatitis C virus (BK strain) NS3 protein, N-terminal domain (186 residues) has been solved by NMR spectroscopy. The, protein is a serine protease with a chymotrypsin-type fold, and is, involved in the maturation of the viral polyprotein. Despite the knowledge, that its activity is enhanced by the action of a viral protein cofactor, NS4A, the mechanism of activation is not yet clear. The analysis of the, folding in solution and the differences from the crystallographic, structures allow the formulation of a model in which, in addition to the, NS4A cofactor, the substrate plays an important role in the activation of, the catalytic mechanism. A unique structural feature is the presence of a, zinc-binding site exposed on the surface, subject to a slow conformational, exchange process. | ||
==About this Structure== | ==About this Structure== | ||
1BT7 is a | 1BT7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Sites: CTS and ZNB. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BT7 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: viral non-structural protein]] | [[Category: viral non-structural protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:27:18 2007'' | ||
