1exz: Difference between revisions

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~~[[Image:1exz.png|left|200px]]~~

===STRUCTURE OF STEM CELL FACTOR===

==~~=STRUCTURE OF STEM CELL FACTOR=~~==

==Disease==

[[http://www.uniprot.org/uniprot/SCF_HUMAN SCF_HUMAN]] Defects in KITLG are the cause of familial progressive hyperpigmentation (FPH) [MIM:[http://omim.org/entry/145250 145250]]; also called melanosis universalis hereditaria (MUH). FPH is an autosomal-dominantly inherited disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age.<ref>PMID:19375057</ref>

==Function==

[[http://www.uniprot.org/uniprot/SCF_HUMAN SCF_HUMAN]] Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Joachimiak, A.]]

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-[[Image:1exz.png|left|200px]]
 {{STRUCTURE_1exz|  PDB=1exz  |  SCENE=  }}
+===STRUCTURE OF STEM CELL FACTOR===
+{{ABSTRACT_PUBMED_10884405}}
-===STRUCTURE OF STEM CELL FACTOR===
+==Disease==
+[[http://www.uniprot.org/uniprot/SCF_HUMAN SCF_HUMAN]] Defects in KITLG are the cause of familial progressive hyperpigmentation (FPH) [MIM:[http://omim.org/entry/145250 145250]]; also called melanosis universalis hereditaria (MUH). FPH is an autosomal-dominantly inherited disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age.<ref>PMID:19375057</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/SCF_HUMAN SCF_HUMAN]] Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
 ==About this Structure==
@@ Line 10: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:010884405</ref><references group="xtra"/>
+<ref group="xtra">PMID:010884405</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Joachimiak, A.]]