4grv: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[ | ==The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)== | ||
<StructureSection load='4grv' size='340' side='right' caption='[[4grv]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4grv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ntsr1, Ntsr, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4grv RCSB], [http://www.ebi.ac.uk/pdbsum/4grv PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In the brain, NTS modulates the activity of dopaminergic systems, opioid-independent analgesia, and the inhibition of food intake; in the gut, NTS regulates a range of digestive processes. Here we present the structure at 2.8 A resolution of Rattus norvegicus NTSR1 in an active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-induced activation of the receptor. The peptide agonist binds to NTSR1 in an extended conformation nearly perpendicular to the membrane plane, with the C terminus oriented towards the receptor core. Our findings provide, to our knowledge, the first insight into the binding mode of a peptide agonist to a GPCR and may support the development of non-peptide ligands that could be useful in the treatment of neurological disorders, cancer and obesity. | |||
Structure of the agonist-bound neurotensin receptor.,White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R Nature. 2012 Oct 25;490(7421):508-13. doi: 10.1038/nature11558. Epub 2012 Oct 10. PMID:23051748<ref>PMID:23051748</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | |||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | |||
== | == References == | ||
[[ | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Enterobacteria phage t4]] | [[Category: Enterobacteria phage t4]] | ||
[[Category: Grisshammer, R | [[Category: Grisshammer, R]] | ||
[[Category: Gvozdenovic-Jeremic, J | [[Category: Gvozdenovic-Jeremic, J]] | ||
[[Category: Kloss, B | [[Category: Kloss, B]] | ||
[[Category: Love, J | [[Category: Love, J]] | ||
[[Category: Noinaj, N | [[Category: Noinaj, N]] | ||
[[Category: Shah, P | [[Category: Shah, P]] | ||
[[Category: Shibata, Y | [[Category: Shibata, Y]] | ||
[[Category: Shiloach, J | [[Category: Shiloach, J]] | ||
[[Category: Tate, C G | [[Category: Tate, C G]] | ||
[[Category: White, J F | [[Category: White, J F]] | ||
[[Category: Xu, F | [[Category: Xu, F]] | ||
[[Category: G-protein]] | [[Category: G-protein]] | ||
[[Category: G-protein coupled receptor]] | [[Category: G-protein coupled receptor]] | ||
[[Category: Neurotensin receptor]] | [[Category: Neurotensin receptor]] | ||
[[Category: Signaling protein-agonist complex]] | [[Category: Signaling protein-agonist complex]] | ||
Revision as of 13:49, 4 January 2015
The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)
| ||||||||||||
