4gwp: Difference between revisions
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[[ | ==Structure of the Mediator Head Module from S. cerevisiae== | ||
<StructureSection load='4gwp' size='340' side='right' caption='[[4gwp]], [[Resolution|resolution]] 4.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gwp]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GWP FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rj1|3rj1]], [[2hzm|2hzm]], [[2hzs|2hzs]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gwp RCSB], [http://www.ebi.ac.uk/pdbsum/4gwp PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription. | |||
Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II.,Robinson PJ, Bushnell DA, Trnka MJ, Burlingame AL, Kornberg RD Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17931-5. doi:, 10.1073/pnas.1215241109. Epub 2012 Oct 15. PMID:23071300<ref>PMID:23071300</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Baker's yeast]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Burlingame, A L]] | |||
[[Category: Burlingame, A L | [[Category: Bushnell, D A]] | ||
[[Category: Bushnell, D A | [[Category: Kornberg, R D]] | ||
[[Category: Kornberg, R D | [[Category: Robinson, P J.J]] | ||
[[Category: Robinson, P J.J | [[Category: Trnka, M J]] | ||
[[Category: Trnka, M J | |||
[[Category: Binding site]] | [[Category: Binding site]] | ||
[[Category: Mediator complex]] | [[Category: Mediator complex]] | ||
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[[Category: Protein subunit]] | [[Category: Protein subunit]] | ||
[[Category: Rna polymerase ii]] | [[Category: Rna polymerase ii]] | ||
[[Category: Structure-activity relationship]] | [[Category: Structure-activity relationship]] | ||
[[Category: Tertiary]] | [[Category: Tertiary]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 09:40, 10 December 2014
Structure of the Mediator Head Module from S. cerevisiae
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