1qbs: Difference between revisions

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[[Image:1qbs.gif|left|200px]]<br /><applet load="1qbs" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1qbs.gif|left|200px]]
caption="1qbs, resolution 1.8&Aring;" />
 
'''HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY'''<br />
{{Structure
|PDB= 1qbs |SIZE=350|CAPTION= <scene name='initialview01'>1qbs</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=DMP:[4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE'>DMP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1QBS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=DMP:'>DMP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBS OCA].  
1QBS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBS OCA].  


==Reference==
==Reference==
Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas., Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al., J Med Chem. 1996 Aug 30;39(18):3514-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8784449 8784449]
Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas., Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al., J Med Chem. 1996 Aug 30;39(18):3514-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8784449 8784449]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: hydrolase (acid proteinase)]]
[[Category: hydrolase (acid proteinase)]]


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