Group:MUZIC:DARP: Difference between revisions
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== Pathology == | == Pathology == | ||
Its altered expression in transgenic mice with increased or decreased PI3K(p110α) activity has a significant impact on functionality of the Z-disc and,subsequently,cardiac function.PI3K(p110α) protects the heart against myocardial infarction. | Its altered expression in transgenic mice with increased or decreased PI3K(p110α) activity has a significant impact on functionality of the Z-disc and,subsequently,cardiac function.PI3K(p110α) protects the heart against myocardial infarction. Together with other genes encoding muscle structural/associated proteins, such as dystroglycan (Dag1), filamin C(Flnc), Rho-associated coiled-coil containing protein kinase 2(Rock2), crystallin, α B (Cryab), Cd151, integrin β 1 binding protein 2(Itgb1bp2/melusin), Lim domain binding 3(Ldb3/cypher), and synaptopodin 2 (Synpo2/myopodin), DARP/Ankrd23 was found up-and down-regulated respectively in the caPI3K (consitutively active PI3K)and dnPI3K(dominant negative PI3K.<ref name='six'>PMID PMC3162444 </ref> | ||
DARP,calpain-10 and calpain-3 play an important role in the regulation of glucose utilization in skeletal muscle. Calpain-3 activity may be regulated by DARP.<ref name='one'>PMID 14583192 </ref | DARP,calpain-10 and calpain-3 play an important role in the regulation of glucose utilization in skeletal muscle. Calpain-3 activity may be regulated by DARP.<ref name='one'>PMID 14583192 </ref | ||
