Group:MUZIC:CARP: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
'''Introduction''' | '''Introduction''' | ||
The cardiac ankyrin repeat protein (CARP/Ankrd1) belongs together with the ankyrin repeat domain 2 (Ankrd2/Arpp) and the diabetes associated ankyrin repeat protein (DARP) to a conserved muscle ankyrin repeat protein (MARP) family<ref name='one'>PMID 14583192</ref>. CARP/Ankrd1 has been independently identified by several groups as a cytokine-inducible transcriptional regulator, a protein that interacts with the transcriptional factor YB-1 and a cardiac doxorubicin-responsive protein<ref name='two'>PMID 7730328</ref>,<ref name='three'>PMID 9043061</ref>. In physiological tissues, Ankrd1 is highly expressed in cardiac muscle and is detectable in skeletal muscles [3]. It is an early differentiation marker during cardiogenesis with a high expression level in developing heart. <ref | |||
name='three'>PMID 9043061</ref>, <ref name='four'>PMID 9278441</ref>. Mutations in the ANKRD1 gene are responsible for human dilated cardiomyopathy. <ref name='five'>PMID 14561590</ref> | name='three'>PMID 9043061</ref>, <ref name='four'>PMID 9278441</ref>. Mutations in the ANKRD1 gene are responsible for human dilated cardiomyopathy. <ref name='five'>PMID 14561590</ref> | ||
