Sandbox Reserved 654: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 41: | Line 41: | ||
== Interaction and Implications == | == Interaction and Implications == | ||
[[Image:http://ars.els-cdn.com/content/image/1-s2.0-S0969212602007542-gr1.jpg |thumb|250 px|right| | [[Image:http://ars.els-cdn.com/content/image/1-s2.0-S0969212602007542-gr1.jpg |thumb|250 px|right| Transcriptional elongation by HIV-1 Tat.]] | ||
Protein lysine acetylation is a crucial regulatory mechanism in chromatin remodeling and transcription activation for numerous cellular processes. The human immunodeficiency virus type 1 (HIV-1) trans-activator protein (Tat), for example, stimulates transcription of the HIV genome and promotes viral replication in cells. But Tat transactivation activity is dependent on the acetylation of Lys-50 by p300/CBP. '''Mujtaba 2002'''. When Tat is acetylated at the Lys-50 residue, Tat dissociates from TAR RNA and binds to the PCAF bromodomain instead. This promotes the formation of a multiprotein complex that is responsible for transcription activation of the HIV genome. | Protein lysine acetylation is a crucial regulatory mechanism in chromatin remodeling and transcription activation for numerous cellular processes. The human immunodeficiency virus type 1 (HIV-1) trans-activator protein (Tat), for example, stimulates transcription of the HIV genome and promotes viral replication in cells. But Tat transactivation activity is dependent on the acetylation of Lys-50 by p300/CBP. '''Mujtaba 2002'''. When Tat is acetylated at the Lys-50 residue, Tat dissociates from TAR RNA and binds to the PCAF bromodomain instead. This promotes the formation of a multiprotein complex that is responsible for transcription activation of the HIV genome. | ||
== Drug Design == | == Drug Design == | ||
