Transferrin receptor: Difference between revisions
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{{STRUCTURE_1suv| PDB=1suv | SIZE=400| SCENE= |right|CAPTION=Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, [[1suv]] }} | {{STRUCTURE_1suv| PDB=1suv | SIZE=400| SCENE= |right|CAPTION=Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, [[1suv]] }} | ||
== Functin == | |||
'''Transferrin receptor''' (TfR) imports iron into the cell by receptor-mediated endocytosis of [[Transferrin|transferrin]]-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin<ref>PMID:10192390</ref>. | |||
== Relevance == | |||
TfR is a potential determinant of iron loading in congenital anemias<ref>PMID:10468869</ref>. | |||
'''Transferrin receptor''' (TfR) imports iron into the cell by receptor-mediated endocytosis of [[Transferrin|transferrin]]-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin. | |||
==3D structures of transferrin receptor== | ==3D structures of transferrin receptor== | ||
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[[3s9l]], [[3s9m]], [[3s9n]] - hTfR ectodomain + transferrin N-lobe<br /> | [[3s9l]], [[3s9m]], [[3s9n]] - hTfR ectodomain + transferrin N-lobe<br /> | ||
[[2nsu]] - hTfR ectodomain in dog retrovirus – EM<br /> | [[2nsu]] - hTfR ectodomain in dog retrovirus – EM<br /> | ||
[[3kas]] - hTfR ectodomain + Machupo virus GP1 | [[3kas]] - hTfR ectodomain + Machupo virus GP1<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
