Sandbox 51: Difference between revisions

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Pancreatic lipase 1hpl (EC 3.1.1.3)  is a an enzyme involved with the digestion and absorption of triacylglycerols (fats) in the intestine.  It is secreted by the pancreas into the duodenum where it participates in the initial stages of breaking down fats into glyercol and three fatty acids.  Lipase is a serine protease and a polar molecule.  The mechanism of action requires Calcium ligands for stability and the coenzyme, colipase, for activation of the lipase mechanism.  The hydrolysis products diffuse across enterocyte membrane and are absorbed into the blood <ref>Voet, D.,etc. "Fundamentals of Biochemistry: Life at the Molecular Level" John Wiley and Sons, Inc: New Jersey, 2008.</ref>.  Due to that role lipase has in digestion of fat, and the growing problem of obesity, there has been increased effort to develop lipase inhibitors for weight loss supplements.