1qdp: Difference between revisions
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'''SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES''' | {{Structure | ||
|PDB= 1qdp |SIZE=350|CAPTION= <scene name='initialview01'>1qdp</scene> | |||
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'''SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QDP is a [ | 1QDP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus., Pallaghy PK, Alewood D, Alewood PF, Norton RS, FEBS Lett. 1997 Dec 15;419(2-3):191-6. PMID:[http:// | Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus., Pallaghy PK, Alewood D, Alewood PF, Norton RS, FEBS Lett. 1997 Dec 15;419(2-3):191-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9428632 9428632] | ||
[[Category: Atrax robustus]] | [[Category: Atrax robustus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: venom]] | [[Category: venom]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:15 2008'' | ||
Revision as of 11:36, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES
Overview
The solution structure of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, has been determined from 2D 1H NMR data. Robustoxin is a polypeptide of 42 residues cross-linked by four disulphide bonds, the connectivities of which were determined from NMR data and trial structure calculations to be 1-15, 8-20, 14-31 and 16-42 (a 1-4/2-6/3-7/5-8 pattern). The structure consists of a small three-stranded, anti-parallel beta-sheet and a series of interlocking gamma-turns at the C-terminus. It also contains a cystine knot, thus placing it in the inhibitor cystine knot motif family of structures, which includes the omega-conotoxins and a number of plant and animal toxins and protease inhibitors. Robustoxin contains three distinct charged patches on its surface, and an extended loop that includes several aromatic and non-polar residues. Both of these structural features may play a role in its binding to the voltage-gated sodium channel.
About this Structure
1QDP is a Single protein structure of sequence from Atrax robustus. Full crystallographic information is available from OCA.
Reference
Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus., Pallaghy PK, Alewood D, Alewood PF, Norton RS, FEBS Lett. 1997 Dec 15;419(2-3):191-6. PMID:9428632
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