1qf4: Difference between revisions
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[[Image:1qf4.jpg|left|200px]] | [[Image:1qf4.jpg|left|200px]] | ||
'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE''' | {{Structure | ||
|PDB= 1qf4 |SIZE=350|CAPTION= <scene name='initialview01'>1qf4</scene>, resolution 2.2Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=RPD:(C8-R)-HYDANTOCIDIN 5'-PHOSPHATE'>RPD</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] | |||
|GENE= | |||
}} | |||
'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QF4 is a [ | 1QF4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF4 OCA]. | ||
==Reference== | ==Reference== | ||
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http:// | An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10556888 10556888] | ||
[[Category: Adenylosuccinate synthase]] | [[Category: Adenylosuccinate synthase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
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[[Category: RPD]] | [[Category: RPD]] | ||
[[Category: gtp-binding]] | [[Category: gtp-binding]] | ||
[[Category: gtp-hydrolysing | [[Category: gtp-hydrolysing enzyme]] | ||
[[Category: purine biosynthesis]] | [[Category: purine biosynthesis]] | ||
[[Category: synthetase]] | [[Category: synthetase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:36:36 2008'' | ||
Revision as of 11:36, 20 March 2008
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| 1qf4, resolution 2.2Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | PO4, MG, GDP and RPD | ||||||||||||
| Activity: | Adenylosuccinate synthase, with EC number 6.3.4.4 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE
Overview
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
About this Structure
1QF4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888
Page seeded by OCA on Thu Mar 20 13:36:36 2008
