4hi9: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974===

~~The entry 4hi9~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

~~Authors~~: ~~Stiegler, A~~.L., ~~Jakoncic,~~ J., ~~Stojanoff, V~~., Chiswell, B.P., ~~Calderwood~~, D.A., ~~Boggon, T.J~~.

==About this Structure==

[[4hi9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI9 OCA].

~~Description~~:

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Boggon, T J.]]

[[Category: Calderwood, D A.]]

[[Category: Chiswell, B P.]]

[[Category: Jakoncic, J.]]

[[Category: Stiegler, A L.]]

[[Category: Stojanoff, V.]]

[[Category: Ankyrin repeat lim domain]]

[[Category: Focal adhesion]]

[[Category: Ilk-pinch]]

[[Category: Signaling protein]]

[[Category: Signaling protein-signaling protein complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hi9|  PDB=4hi9  |  SCENE=  }}
+===1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974===
-The entry 4hi9 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
-Authors: Stiegler, A.L., Jakoncic, J., Stojanoff, V., Chiswell, B.P., Calderwood, D.A., Boggon, T.J.
+==About this Structure==
+[[4hi9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI9 OCA].
-Description:
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Boggon, T J.]]
+[[Category: Calderwood, D A.]]
+[[Category: Chiswell, B P.]]
+[[Category: Jakoncic, J.]]
+[[Category: Stiegler, A L.]]
+[[Category: Stojanoff, V.]]
+[[Category: Ankyrin repeat lim domain]]
+[[Category: Focal adhesion]]
+[[Category: Ilk-pinch]]
+[[Category: Signaling protein]]
+[[Category: Signaling protein-signaling protein complex]]