1qf5: Difference between revisions

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[[Image:1qf5.jpg|left|200px]]<br /><applet load="1qf5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1qf5.jpg|left|200px]]
caption="1qf5, resolution 2.0&Aring;" />
 
'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''<br />
{{Structure
|PDB= 1qf5 |SIZE=350|CAPTION= <scene name='initialview01'>1qf5</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=RPL:(C8-S)-HYDANTOCIDIN 5'-PHOSPHATE'>RPL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4]
|GENE=
}}
 
'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1QF5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=RPL:'>RPL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF5 OCA].  
1QF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF5 OCA].  


==Reference==
==Reference==
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10556888 10556888]
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10556888 10556888]
[[Category: Adenylosuccinate synthase]]
[[Category: Adenylosuccinate synthase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: RPL]]
[[Category: RPL]]
[[Category: gtp-binding]]
[[Category: gtp-binding]]
[[Category: gtp-hydrolysing enzymes]]
[[Category: gtp-hydrolysing enzyme]]
[[Category: purine biosynthesis]]
[[Category: purine biosynthesis]]
[[Category: synthetase]]
[[Category: synthetase]]


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