1qhr: Difference between revisions

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[[Image:1qhr.gif|left|200px]]<br /><applet load="1qhr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1qhr.gif|left|200px]]
caption="1qhr, resolution 2.2&Aring;" />
 
'''NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS'''<br />
{{Structure
|PDB= 1qhr |SIZE=350|CAPTION= <scene name='initialview01'>1qhr</scene>, resolution 2.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=157:6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE'>157</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
|GENE=
}}
 
'''NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1QHR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=157:'>157</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHR OCA].  
1QHR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHR OCA].  


==Reference==
==Reference==
Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template., Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A, Biochemistry. 1999 Jun 22;38(25):7969-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10387040 10387040]
Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template., Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A, Biochemistry. 1999 Jun 22;38(25):7969-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10387040 10387040]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: trypsin like proteinase]]
[[Category: trypsin like proteinase]]


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