1flk: Difference between revisions

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~~[[Image:1flk.png|left|200px]]~~

===MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3===

===~~MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY~~ TRAF3~~===~~

==Disease==

[[http://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN]] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[http://omim.org/entry/614849 614849]]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref>

~~{{ABSTRACT_PUBMED_10984535}}~~

==Function==

[[http://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN]] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref><ref>PMID:15084608</ref><ref>PMID:17991829</ref><ref>PMID:20097753</ref><ref>PMID:20185819</ref><ref>PMID:19937093</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Chiou, C K.]]

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@@ Line 1: / Line 1: @@
-[[Image:1flk.png|left|200px]]
 {{STRUCTURE_1flk|  PDB=1flk  |  SCENE=  }}
+===MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3===
+{{ABSTRACT_PUBMED_10984535}}
-===MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3===
+==Disease==
+[[http://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN]] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[http://omim.org/entry/614849 614849]]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref>
-{{ABSTRACT_PUBMED_10984535}}
+==Function==
+[[http://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN]] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref><ref>PMID:15084608</ref><ref>PMID:17991829</ref><ref>PMID:20097753</ref><ref>PMID:20185819</ref><ref>PMID:19937093</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:010984535</ref><references group="xtra"/>
+<ref group="xtra">PMID:010984535</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Chiou, C K.]]