1qwf: Difference between revisions
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[[Image:1qwf.jpg|left|200px]] | [[Image:1qwf.jpg|left|200px]] | ||
'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12''' | {{Structure | ||
|PDB= 1qwf |SIZE=350|CAPTION= <scene name='initialview01'>1qwf</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | |||
|GENE= CHICKEN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11876 Avian sarcoma virus]) | |||
}} | |||
'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QWF is a [ | 1QWF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWF OCA]. | ||
==Reference== | ==Reference== | ||
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:[http:// | Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8618911 8618911] | ||
[[Category: Avian sarcoma virus]] | [[Category: Avian sarcoma virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: src sh3 domain]] | [[Category: src sh3 domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:43:36 2008'' | ||
Revision as of 11:43, 20 March 2008
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| 1qwf | |||||||||||||
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| Gene: | CHICKEN (Avian sarcoma virus) | ||||||||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12
Overview
Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity.
About this Structure
1QWF is a Single protein structure of sequence from Avian sarcoma virus. Full crystallographic information is available from OCA.
Reference
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:8618911
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