Hiv env proteins: Difference between revisions

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== gp120 Binding ==

gp120 is responsible for the binding of HIV to CD4 cells. "Binding of gp120 to the primary receptor CD4 and coreceptor (for example, CCR5 and CXCR4) induces large conformational changes, which then trigger dissociation of gp120 and a cascade of refolding events in gp41" <ref name=Guan>PMID: 21076402 </ref>. In the unliganded state, the <scene name='Sandbox/Gp120_v1_v2_loops/1'>V1/V2 loops</scene> are located at the center of the apex of the trimer. However, ~~in the~~ <scene name='Sandbox/Gp120_v1_v2_loops/2'>CD4 ~~bound state~~</scene>, the V1/V2 loops undergo an outward rotational change that expose the central gp41 proteins at the base of the Env protein.

gp120 is responsible for the binding of HIV to CD4 cells. "Binding of gp120 to the primary receptor CD4 and coreceptor (for example, CCR5 and CXCR4) induces large conformational changes, which then trigger dissociation of gp120 and a cascade of refolding events in gp41" <ref name=Guan>PMID: 21076402 </ref>. In the unliganded state, the <scene name='Sandbox/Gp120_v1_v2_loops/1'>V1/V2 loops</scene> are located at the center of the apex of the trimer and hold the trimer together. However, when <scene name='Sandbox/Gp120_v1_v2_loops/2'>CD4</scene> binds to gp120, the V1/V2 loops undergo an outward rotational change that expose the central gp41 proteins at the base of the Env protein. gp120 is often complexed with <scene name='Hiv_env_proteins/Cd4_gp120_complex/1'>CD4</scene> and an antibody Fab (17b-Fab). "The 17b antibody has been shown to stabilize and lock gp120 in the CD4-bound conformation" <ref name=Nick>PMID: 18668044 </ref>.

Hiv env proteins: Difference between revisions

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Revision as of 06:19, 27 November 2012 view source Nicholas Flores (talk \| contribs) 24 edits No edit summary ← Older edit		Revision as of 07:36, 27 November 2012 view source Nicholas Flores (talk \| contribs) 24 edits No edit summary Newer edit →
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	== gp120 Binding ==		== gp120 Binding ==
	gp120 is responsible for the binding of HIV to CD4 cells. "Binding of gp120 to the primary receptor CD4 and coreceptor (for example, CCR5 and CXCR4) induces large conformational changes, which then trigger dissociation of gp120 and a cascade of refolding events in gp41" <ref name=Guan>PMID: 21076402 </ref>. In the unliganded state, the <scene name='Sandbox/Gp120_v1_v2_loops/1'>V1/V2 loops</scene> are located at the center of the apex of the trimer. However, ~~in the~~ <scene name='Sandbox/Gp120_v1_v2_loops/2'>CD4 ~~bound state~~</scene>, the V1/V2 loops undergo an outward rotational change that expose the central gp41 proteins at the base of the Env protein.		gp120 is responsible for the binding of HIV to CD4 cells. "Binding of gp120 to the primary receptor CD4 and coreceptor (for example, CCR5 and CXCR4) induces large conformational changes, which then trigger dissociation of gp120 and a cascade of refolding events in gp41" <ref name=Guan>PMID: 21076402 </ref>. In the unliganded state, the <scene name='Sandbox/Gp120_v1_v2_loops/1'>V1/V2 loops</scene> are located at the center of the apex of the trimer and hold the trimer together. However, when <scene name='Sandbox/Gp120_v1_v2_loops/2'>CD4</scene> binds to gp120, the V1/V2 loops undergo an outward rotational change that expose the central gp41 proteins at the base of the Env protein. gp120 is often complexed with <scene name='Hiv_env_proteins/Cd4_gp120_complex/1'>CD4</scene> and an antibody Fab (17b-Fab). "The 17b antibody has been shown to stabilize and lock gp120 in the CD4-bound conformation" <ref name=Nick>PMID: 18668044 </ref>.