Sandbox 645: Difference between revisions
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==Future Research Focus== | |||
The main goals for future research in this field are i)the design of better pharmacological agents and avoid severe side effects | |||
ii)achieving era direction of the virus and possibly definitive cure of the disease.. | |||
As been mentioned..the pol gene of HIV-1 encodes for three enzymes,protease (PR),reverse transcriptase (RT) and integrase (IN).More than 10 drugs targeting two of these enzymes,PR and RT have been approved by FDA.at present,there are no clinically useful agents that inhibit the third enzyme(IN).Researchers try to emphasize the proposed drug binding sites on (IN )in order to find inhibitors that can bind to them.This problem happened due to the inherent nature of (IN) and insufficient structural information,structure based inhibitor design selective for IN has kept pace. | |||
