1qxw: Difference between revisions

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[[Image:1qxw.jpg|left|200px]]<br /><applet load="1qxw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1qxw.jpg|left|200px]]
caption="1qxw, resolution 1.67&Aring;" />
 
'''Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135.'''<br />
{{Structure
|PDB= 1qxw |SIZE=350|CAPTION= <scene name='initialview01'>1qxw</scene>, resolution 1.67&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=M1C:(3S)-3-AMINO-1-(CYCLOPROPYLAMINO)HEPTANE-2,2-DIOL'>M1C</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18]
|GENE=
}}
 
'''Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1QXW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=CO:'>CO</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=M1C:'>M1C</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXW OCA].  
1QXW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXW OCA].  


==Reference==
==Reference==
Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate., Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C, J Med Chem. 2004 Mar 11;47(6):1325-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14998322 14998322]
Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate., Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C, J Med Chem. 2004 Mar 11;47(6):1325-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14998322 14998322]
[[Category: Methionyl aminopeptidase]]
[[Category: Methionyl aminopeptidase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: pita bread fold]]
[[Category: pita bread fold]]


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