Human Prion Protein Dimer: Difference between revisions
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The following residue alterations confer increased susceptibility to the unfolding of these alpha helices characteristic of spongiform encephalopathies. | The following residue alterations confer increased susceptibility to the unfolding of these alpha helices characteristic of spongiform encephalopathies. | ||
Residue 129 Val-->Met confers increased susceptibility to contracting spongiform encephalopathies. The alteration from 129 valine to 129 methionine does not majorly change electrostatics as both are hydrophobic. The methionine group is bulkier however. Due to the limitations of viewing the monomeric form, <scene name='User:Erin_May/Sandbox_1/Methionine_129/1'>Methionine 129</scene>, does not offer a possible mechanism of unfolding or aggregation. This single residue, however has incredible actions. As of January 2010, only individuals with homozygous Metionine 129 had been diagnosed with infectious Creutzfeldt–Jakob disease.<ref name="Lee">PMID:19927125</ref> | Residue 129 Val-->Met confers increased susceptibility to contracting spongiform encephalopathies. The alteration from 129 valine to 129 methionine does not majorly change electrostatics as both are hydrophobic. The methionine group is bulkier however. Due to the limitations of viewing the monomeric form, <scene name='User:Erin_May/Sandbox_1/Methionine_129/1'>Methionine 129</scene>, it does not offer a possible mechanism of unfolding or aggregation. This single residue, however has incredible actions. As of January 2010, only individuals with homozygous Metionine 129 had been diagnosed with infectious Creutzfeldt–Jakob disease.<ref name="Lee">PMID:19927125</ref> | ||
<scene name='User:Erin_May/Sandbox_1/Species_variable_domain/1'>Residues 164 to 170</scene> exhibit species specific residues. This region is most variable between species. Residue shifts in this section increase or decrease susceptibility from inter-species transmission of TSE's. The more similar this region is between species, the more likely each are able to transfer infectious prions between the two.<ref name="Lee">PMID:19927125</ref> | <scene name='User:Erin_May/Sandbox_1/Species_variable_domain/1'>Residues 164 to 170</scene> exhibit species specific residues. This region is most variable between species. Residue shifts in this section increase or decrease susceptibility from inter-species transmission of TSE's. The more similar this region is between species, the more likely each are able to transfer infectious prions between the two.<ref name="Lee">PMID:19927125</ref> | ||
